Since 1993, David Sherr’s laboratory has conducted research on how common environmental pollutants act like immunosuppressive drugs, compromising immune responses and altering immune cell development–work that has its roots in Dr. Sherr’s graduate studies on the ontogeny of lymphocyte development. Today his lab uses technologies including bone marrow cultures and transgenic mice. Dr. Sherr is also conducting studies related to the molecular mechanisms that initiate and maintain breast cancer. These studies focus on the role of an environmental chemical receptor (the AhR) in dysregulated tumor cell growth and resistance to death signals. A third area of investigation centers on the use of molecular and computational technologies to predict the ability of environmental chemicals to induce cancer, with an emphasis on breast cancer. Dr. Sherr earned his B.A. in Biology from Brandeis University and his Ph.D. in Microbiology and Immunology from Cornell University. Dr. Sherr came to BUSPH from the faculty of Harvard Medical School, where he had earlier been a postdoctoral fellow in the department of Nobel Laureate Baruj Benacerraf. The Sherr laboratory has been continually funded since 1984 by the National Institutes of Health. The Sherr Laboratory currently is funded by research grants from the National Institute of Environmental Health Sciences and the EPA’s Superfund Basic Research Program. He has published over 100 peer-reviewed articles. Dr. Sherr is the Director of the Boston University Immunology Training Program and a member of the BU Hematology/Oncology Training Program, the BU Cancer Center, and the Amyloid Treatment and Research Center. He has trained 21 postdoctoral fellows and 10 predoctoral fellows.
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